Combat has 2 hyperthermic drug delivery systems for the treatment of bladder cancer and cancers within the peritoneal cavity.
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What differentiates the company
What our experts say
I envisage a great potential. It is a simple idea with a great application, and of course robust innovation.
It is a promising proposal supported by sales and IP.
The final ratings
Simple and beautiful: Hyperthermic Oncological Therapy
Cancer cells could be thought of as runaway, survivalist versions of normal cells; they reproduce out of control and keep living when they should die and be replaced. They are essentially mutants who ignore all normal cell behavior and cause mayhem by growing out of control. But let’s not forget that the body has trouble understanding this; to our body, a cell is a cell, regardless of how twisted and mutated it has become.
But that doesn’t mean that these cells aren’t different to normal cells. For example, they are very hungry – these cells consume more energy than ordinary ones. But there is a very particular thing about them that can be used to kill them: they just can’t take the heat.
“The combination of heat and chemotherapy is very effective against tumors”
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When a cell is too hot, it gets damaged beyond repair and does what all normal, well-behaved cells do: it turns itself in and volunteers to be destroyed. Heat-damaged cells plant on their outer membrane proteins called Heat Stress Signals, a sort of “flag” that signals the immune system to kill the cell and absorb it – this is our body’s normal recycling system.
The really interesting point is this: healthy cells are generally OK up to 43,5 celsius, but most cancer cells can’t take anything above 41. Above this, things start happening: their outer walls become soft and permeable, making it all the easier for drugs to penetrate the cell. Not only that: they also start sending out heat stress signals. And as we know, sending those out means getting destroyed by the Immune system.
All in all, it’s quite straightforward: the combination of heat and chemotherapy is very effective against tumors. So… forget all about complicated biotechnological treatments; washing a tumor in warm chemotherapy drugs is a great way to get rid of it.
Based on this, Combat Medical have developed high precision, specialised equipment capable of circulating chemotherapy drugs at just the right temperature and with the right levels of agitation in bladder, colorectal and stomach cancers.
Early clinical results in major UK and Spanish hospitals are showing >80% disease-free survival rates and over 17000 treatments have already been carried out, meaning this clinical method may already be a powerful new weapon in the arsenal against Cancer.
Company Business Plan
Who we are
With over 14 years of experience specifically in medical device management he was part of the team that led a successful US$330m IPO listing of The Laryngeal Mask Company (LMA) which successfully reformed the anesthesia market.
Has founded, commercialized and sold several businesses, has invented and patented several products and has over 20 years of experience in getting innovative medical products to market.
Formerly a senior investment banker in the Asia Pacific capital markets at Morgan Stanley. Ronnie has raised over US$25 billion across sectors and stages of business.
Purpose of the project
FROM PROBLEM TO SOLUTION
Other hyperthermia solutions have shown excellent clinical results, but failed commercially because they are too expensive, have patient tolerability issues (40% burns), are difficult to use and take up significant amounts of clinician’s time making them unscalable for mainstream use. Through Combat’s IP and know-how a technology platform has been created that has solved this and is easy to use. Its patented aluminum heat exchanger controls the temperature delivered within ±0.2°C, fluid flow rates and pressure delivered to the patient and the cancer (Duke Uni, USA). Hyperthermic drug delivery results in improved survival rates and significantly reduces recurrence rates and treatment cost.
Combat has 2 hyperthermic drug delivery systems for the treatment of bladder cancer and cancers within the peritoneal cavity. These systems are simple, robust, CE marked, and the subject of 5 patent application families (some granted). Having placed over 17,000 kits on the market, Combat’s systems effectiveness has been validated. Its patented technologies enable the accurate control of temperature, flow and pressure. This allows for up to 10 times more drug to be absorbed, creates a natural immune response, and by delivering temperature within a tightly controlled range, it disrupts the cancer cells while leaving the good cells unaffected, leading to the death of the cancer cells.